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+ servings
close up of pot roast sandwich with melty cheese, caramelized onions and tender pot roast
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5 from 2 votes

Cheesy Pot Roast Sandwich

Learn how to make put those pot roast leftovers to delicious use! A deliciously cheesy pot roast sandwich topped with caramelized onions.
Prep Time2 mins
Cook Time8 mins
Total Time10 mins
Course: Main Course
Cuisine: American
Keyword: pot roast grilled cheese, pot roast sandwich
Servings: 1 sandwich
Calories: 537kcal


  • Air fryer or skillet


  • 1 cup leftover pot roast I used Mississippi pot roast
  • 2 slices bread
  • 3 slices cheese I used American cheese
  • cup caramelized onions
  • butter for spreading on bread
  • 1 Tablespoon grated parmesan cheese


  • Begin by buttering one slide of each piece of bread. Evenly sprinkle parmesan cheese on top.
    2 slices bread, butter, 1 Tablespoon grated parmesan cheese
    spreading butter and parmesan cheese on a slice on bread for a pot roast sandwich
  • Flip one piece over. Layer 2 slices of cheese on the bread. Next, layer your leftover pot roast on top of the cheese slices.
    3 slices cheese, 1 cup leftover pot roast
    topping a slice of bread with American cheese and pot roast
  • Top with another slice of cheese, then layer with caramelized onions.
    ⅓ cup caramelized onions
    adding more cheese and sautéed onions to a slice of bread
  • Top with your other slice of bread, butter side up.
    2 slices bread
    topping pot roast sandwich with another piece of bread topped with butter and parmesan cheese
  • Place in the air fryer at 350°F for 5 minutes on one side.
    pot roast sandwich in the air fryer
  • After 5 minutes, flip and cook an additional 4 minutes, or until golden brown. Serve and enjoy!
    cooked pot roast sandwich in the air fryer



  • Can't forget about the au jus: Don't forget to add a few spoonfuls of leftover au jus on top of your sandwich for extra added moisture.
  • Try out a different cheese: Mix up the flavors and try out a different cheese like mozzarella, provolone, or pepper jack cheese.
  • Find your ideal bread: I love serving my pot roast sandwiches on hard, crusty bread.
  • Add more vegetables: Like mushrooms, or add some peppers onto your sandwich!


Serving: 1sandwich | Calories: 537kcal | Carbohydrates: 35g | Protein: 60g | Fat: 16g | Saturated Fat: 6g | Polyunsaturated Fat: 2g | Monounsaturated Fat: 6g | Trans Fat: 0.02g | Cholesterol: 158mg | Sodium: 546mg | Potassium: 1002mg | Fiber: 4g | Sugar: 7g | Vitamin A: 58IU | Vitamin C: 6mg | Calcium: 169mg | Iron: 7mg