Place beef in a bowl, then add salt, garlic powder, onion powder, black pepper and Worcestershire sauce.
Using your hands, mix together the hamburger mixture until combined. Separate into 4 balls. Form each ball into a patty.
Heat air fryer to 360°F. Place patties in the air fryer. Cook for 7 minutes on each side. Serve on a bun and garnish with garlic butter and your favorite toppings. Enjoy!